INTRODUCTION
Lipid emulsions are commonly used to insure the delivery of
antibiotics or liposoluble drugs in vaccine. These Injectable
lipid emulsions are generally made with:
• Purified natural oil (soya, sesame, olive, cod-liver oil etc.)
• Aqueous phase
• Emulsifiers (natural e.g soya lecithins or synthetic e.g
glycerol monostearate)
They must stay stable during the duration of use of the
emulsions and the diameter of the particles/droplets must be
inferior to 5µm in order to void the risk of embolism. The
addition of active to the emulsion affects their properties and
so all combination has to be control.
In this note, the effect of an antibiotic on 4 different lipid
emulsions is evaluated.
