Protein denaturation monitored with non-invasive SMLS



Proteins are used in various fields such as food, pharmaceutics,
biochemistry and biology, particularly at high concentration. Medicinal
research is largely challenged with the formulation of highly concentrated
protein dispersions, particularly for long term delivery in order to reduce
the frequency of injections. The proteins ability to remain well dispersed,
avoid aggregation and keep its spatial configuration constant is driven by
factors such as temperature, salt concentration and amino acid addition.
Protein aggregation is often studied by viscosity measurements as
protein denaturation leads to an increase in viscosity. DLS and zeta
potential measurements are also common methods but require heavy