INTRODUCTION
Nano and micro suspensions are widely used in the industry but their real dispersion state remains unknown or not well
characterized in their native and concentrated form (slurries, vaccines…).
Indeed common measurement techniques may alter the dispersed phase or the apparent particle size due to the principle
of measurement (microscopy, centrifugation, FFF, sieving, filtration) or the sample dilution (DLS, PTA, laser diffraction).
This is especially the case for samples containing agglomerates which may breakdown because of measurement
conditions such as shear stress (pumping, flowing, filtration, and centrifugation) or heavy dilutions.
Because the industry requires particles analysis in the native suspension form for product development, regulatory
compliance or health and safety tests, here we propose a method to assess the mean particles size and agglomeration
state in concentrated media. The measurements were done with well-calibrated polystyrene and titanium dioxide
particles.
