Mitochondrial Dysfunction as Assessed by an ABCA2 Breath Test and its Relationship to Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

Liver fibrosis is caused by non-alcoholic fatty liver disease (NAFLD); the usual way of assessing such damage is via a liver biopsy, which is invasive and an uncomfortable procedure for patients. Mitochondrial dysfunction plays a role in liver fibrosis, so an alternative approach to assessing liver damage is the use of an isotopic breath test with a Sercon ABCA2.The 13C-ketoisocaproate (13C-KICA) breath test evaluates hepatic mitochondrial function. The aim of this study was to determine associations between the 13C-KICA breath test and measurement of liver fibrosis.